Gut Microbes Affect Weight After Gastric Bypass

Gut Microbe

A study in mice suggests that gastric bypass surgery may result in weight loss in part by altering microbes in the gut. The finding may lead to a better understanding of how microbes influence energy balance.

Gastric Bypass Is A Type Of Surgery Used To Treat Severe Obesity

Gastric bypass is a type of surgery used to treat severe obesity. In a procedure known as Roux-en-Y gastric bypass (RYGB), part of the stomach and small intestine are removed. The procedure results in significant weight loss as well as improvements in associated conditions such as type 2 diabetes. Decreased calories, however, can’t fully account for all these effects.

The digestive tract is home to trillions of microbes, both helpful and harmful, that outnumber the body’s cells by 10 to 1. A team of researchers led by Dr. Alice P. Liou and Dr. Lee M. Kaplan from Massachusetts General Hospital and Dr. Peter J. Turnbaugh from Harvard University wondered whether some of the benefits of RYGB surgery might come from changes in digestive tract microbes.

To investigate, the researchers performed RYGB surgery or sham surgery on obese mice. The work was funded in part by NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and National Institute of General Medical Sciences (NIGMS). Some of the mice that had sham surgery were given a restricted diet so their weight would match the weight of those that underwent RYGB surgery.


 Get The Latest By Email

Weekly Magazine Daily Inspiration

To assess the types of microbes found in the animals' guts, the team sequenced and compared 16S ribosomal RNA (rRNA) genes from mouse fecal samples collected over 12 weeks. A central component of the protein-manufacturing machinery of all living cells, rRNA is often used as a marker to identify different bacteria.

Effects Of RYGB Surgery Are Due In Part To Changes In The Gut Microbial Community

The researchers reported in the March 27, 2013, issue of Science Translational Medicine that mice that underwent RYGB surgery lost 29% of their body weight within 3 weeks. This was accompanied by a decrease in fat mass despite no change in net food intake. The RYGB surgery resulted in a marked change in the composition of microbes in the gut, with changes seen as early as a week after surgery. Alterations seen throughout the entire digestive tract were similar to those previously reported in humans and rats.

The researchers next performed a series of “fecal transplants. They collected samples of gut microbial communities from mice that had undergone gastric bypass, sham surgery, or sham surgery plus restricted diet. The samples were put into the stomachs of lean mice that were germ free and thus had no preexisting gut microbial communities.

The mice that received microbes from the RYGB surgery mice lost weight and had less fat mass than mice that received microbes from either group of sham surgery mice. The mice that received the RYGB-mouse microbes had a food intake similar to mice that remained germ free.

This research shows that the beneficial effects of RYGB surgery are due in part to changes in the gut microbial community. Our findings emphasize the importance of accounting for the influence of the trillions of microbes that inhabit our body when we consider obesity and other complex diseases,” Turnbaugh says. Article Source: NIH Research Matters

More By This Author

AVAILABLE LANGUAGES

English Afrikaans Arabic Chinese (Simplified) Chinese (Traditional) Danish Dutch Filipino Finnish French German Greek Hebrew Hindi Hungarian Indonesian Italian Japanese Korean Malay Norwegian Persian Polish Portuguese Romanian Russian Spanish Swahili Swedish Thai Turkish Ukrainian Urdu Vietnamese

follow InnerSelf on

facebook icontwitter iconyoutube iconinstagram iconpintrest iconrss icon

 Get The Latest By Email

Weekly Magazine Daily Inspiration

Saturday, 08 May 2021 08:43

Humanity has always had a rocky relationship with wasps. They are one of those insects that we love to hate. We value bees (which also sting) because they pollinate our crops and make honey

Wednesday, 26 July 2023 17:18

Do you know why junk food is so addictive? Are you craving sweets yet? If you've ever wondered why junk food can be so addictive, you're not alone.

Wednesday, 19 May 2021 09:40

To “cry poor mouth” is an expression used to habitually complain about a lack of money. A literal poor mouth, however, represents one of the most widespread global diseases: tooth decay.

Thursday, 27 July 2023 20:13

How to train your body for hot weather if you are active or work outdoors Heat exposure is inevitable for those who work or are active outdoors. (Shutterstock) Global warming is making outdoor...

Friday, 14 May 2021 16:24

The chakras set the frequencies that give rise to every aspect of the human experience. The foods we eat have consciousness and provide an energetic blueprint that stabilizes and entrains...

Wednesday, 26 July 2023 12:55

With the rising cost of living, gyms memberships and fitness classes are becoming increasingly unaffordable. But the good news is you can make just as much progress at home.

New Attitudes - New Possibilities

InnerSelf.comClimateImpactNews.com | InnerPower.net
MightyNatural.com | WholisticPolitics.com | InnerSelf Market
Copyright ©1985 - 2021 InnerSelf Publications. All Rights Reserved.